55  Delivery Metrics & KPIs

55.1 Purpose

Metrics and KPIs provide quantitative visibility into trial performance.

They allow project management to: - detect problems early, - track trends, - and justify decisions.

Without metrics, PM is blind.


55.2 Key Performance Domains

Typical KPI categories:

Domain Examples
Start-Up % sites activated
Monitoring Visit completion rate
Safety SAE reporting timeliness
Data Quality Query aging
Quality Deviation rate
Delivery Milestone adherence

55.3 Examples of Operational KPIs

55.3.1 Monitoring

  • % scheduled visits completed
  • average days to report findings

55.3.2 Data Quality

  • open queries per subject
  • median query resolution time

55.3.3 Safety

  • % SAEs reported within 24 hours
  • unresolved safety follow-ups

55.3.4 Quality

  • deviations per site
  • CAPA closure time

55.4 Leading vs Lagging Indicators

Type Meaning
Leading Predict future problems
Lagging Confirm past performance

Examples: - High query aging → leading indicator
- Missed DBL → lagging indicator

Effective PM prioritizes leading indicators.


55.5 KPIs as Decision Inputs

Metrics are not for reporting. They are for decision-making.

KPIs inform: - resource reallocation - escalation - vendor performance - risk prioritization

KPIs are a control system, not a scoreboard.