69 Immune-Related Adverse Events (irAEs)

69.1 What are irAEs?

Adverse events caused by immune activation (e.g., checkpoint inhibitors).

69.2 Common irAEs

Colitis
Pneumonitis
Hepatitis
Endocrinopathies

69.3 CRA Oversight

Long follow-up periods
Delayed onset
Steroid treatment documentation
Re-challenge decisions